Trading Commodity CFDs can occur nearly around the clock, closely mirroring the trading hours of the underlying commodity markets.  

Commodity futures, which serve as the foundation for many of these CFDs, are generally available for trading almost 24 hours a day. Major exchanges like the Chicago Mercantile Exchange (CME) and the Intercontinental Exchange (ICE) allow trading to start at 6:00 PM EST on Sunday and continue until 5:00 PM EST on Friday, with a brief pause each day from 5:00 PM to 6:00 PM EST. 

Spot trading for commodities typically occurs during regular business hours, from 9:00 AM to 5:00 PM EST. 

The highest liquidity and volatility for Commodity CFDs generally occur during U.S. market hours, specifically from 9:30 AM to 4:00 PM EST. During this period, both U.S. and international markets are actively trading, resulting in tighter spreads and better execution prices for CFD traders.  

Additionally, overlaps with European trading hours, from 3:00 AM to 11:00 AM EST, provide further opportunities. The increased activity during this timeframe enhances liquidity and can lead to significant price movements.